Entity Details

Primary name LIS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43034
EntryNameLIS1_HUMAN
FullNamePlatelet-activating factor acetylhydrolase IB subunit beta
TaxID9606
Evidenceevidence at protein level
Length410
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAFAH1B1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000226 microtubule cytoskeleton organization
GO:0000235 astral microtubule
GO:0000776 kinetochore
GO:0001675 acrosome assembly
GO:0001764 neuron migration
GO:0005635 nuclear envelope
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0007017 microtubule-based process
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0007268 chemical synaptic transmission
GO:0007281 germ cell development
GO:0007405 neuroblast proliferation
GO:0007611 learning or memory
GO:0008017 microtubule binding
GO:0008090 retrograde axonal transport
GO:0008201 heparin binding
GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex
GO:0008344 adult locomotory behavior
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016042 lipid catabolic process
GO:0019226 transmission of nerve impulse
GO:0021540 corpus callosum morphogenesis
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0021987 cerebral cortex development
GO:0030036 actin cytoskeleton organization
GO:0031023 microtubule organizing center organization
GO:0031514 motile cilium
GO:0031965 nuclear membrane
GO:0034452 dynactin binding
GO:0038026 reelin-mediated signaling pathway
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043274 phospholipase binding
GO:0045202 synapse
GO:0046469 platelet activating factor metabolic process
GO:0046982 protein heterodimerization activity
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0048854 brain morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051010 microtubule plus-end binding
GO:0051012 microtubule sliding
GO:0051219 phosphoprotein binding
GO:0051301 cell division
GO:0070062 extracellular exosome
GO:0070840 dynein complex binding
GO:0097711 ciliary basal body-plasma membrane docking
GO:1904115 axon cytoplasm
GO:2000574 obsolete regulation of microtubule motor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus membrane

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR006594 LIS1 homology motifDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017252 Dynein regulator LIS1FamilyFamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037190 LIS1, N-terminalFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LIS1_HUMANNUDC_MOUSEIntAct11163258 details
LIS1_HUMANNDE1_MOUSEBioGRID, IntAct11163258 20360068 details