Entity Details

Primary name GLP1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43220
EntryNameGLP1R_HUMAN
FullNameGlucagon-like peptide 1 receptor
TaxID9606
Evidenceevidence at protein level
Length463
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesGLP1R

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004888 transmembrane signaling receptor activity
GO:0004967 glucagon receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008528 G protein-coupled peptide receptor activity
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019933 cAMP-mediated signaling
GO:0044508 glucagon-like peptide 1 receptor activity
GO:0045777 positive regulation of blood pressure
GO:0050796 regulation of insulin secretion

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptorFamilyFamily
IPR003292 GPCR, family 2, glucagon-like peptide-1 receptorFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00040 GlucagonDrugbankbiotech
DB01276 ExenatideDrugbankbiotech
DB06655 LiraglutideDrugbankbiotech
DB09043 AlbiglutideDrugbankbiotech
DB09045 DulaglutideDrugbankbiotech
DB09265 LixisenatideDrugbanksmall molecule
DB13928 SemaglutideDrugbanksmall molecule