Entity Details

Primary name MK08_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45983
EntryNameMK08_HUMAN
FullNameMitogen-activated protein kinase 8
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK8

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009411 response to UV
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0016241 regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0030424 axon
GO:0031281 positive regulation of cyclase activity
GO:0031343 positive regulation of cell killing
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035033 histone deacetylase regulator activity
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045202 synapse
GO:0048511 rhythmic process
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051247 positive regulation of protein metabolic process
GO:0051403 stress-activated MAPK cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071345 cellular response to cytokine stimulus
GO:0090045 positive regulation of deacetylase activity
GO:0097441 basal dendrite
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902595 regulation of DNA replication origin binding

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008351 Mitogen-activated protein (MAP) kinase, JNKFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01782 PyrazolanthroneDrugbanksmall molecule
DB07218 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONEDrugbanksmall molecule
DB07268 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDEDrugbanksmall molecule
DB07272 N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDEDrugbanksmall molecule
DB07276 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDEDrugbanksmall molecule
DB07845 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamideDrugbanksmall molecule
DB15624 HalicinDrugbanksmall molecule