Entity Details

Primary name MP2K4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45985
EntryNameMP2K4_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 4
TaxID9606
Evidenceevidence at protein level
Length399
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K4

GO terms

Show/Hide Table
GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0008545 JUN kinase kinase activity
GO:0009611 response to wounding
GO:0030424 axon
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032839 dendrite cytoplasm
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043204 perikaryon
GO:0043525 positive regulation of neuron apoptotic process
GO:0045740 positive regulation of DNA replication
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071260 cellular response to mechanical stimulus
GO:0072709 cellular response to sorbitol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000672 negative regulation of motor neuron apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MP2K4_HUMANFLNA_MOUSEBioGRID9006895 details