Entity Details

Primary name CCL2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP10148
EntryNameCCL2_MOUSE
FullNameC-C motif chemokine 2
TaxID10090
Evidenceevidence at protein level
Length148
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCcl2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001664 G protein-coupled receptor binding
GO:0001666 response to hypoxia
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002544 chronic inflammatory response
GO:0002548 monocyte chemotaxis
GO:0002687 positive regulation of leukocyte migration
GO:0002693 positive regulation of cellular extravasation
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0007010 cytoskeleton organization
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007568 aging
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0008347 glial cell migration
GO:0008360 regulation of cell shape
GO:0009408 response to heat
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0010332 response to gamma radiation
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010759 positive regulation of macrophage chemotaxis
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0022409 positive regulation of cell-cell adhesion
GO:0030139 endocytic vesicle
GO:0030425 dendrite
GO:0030593 neutrophil chemotaxis
GO:0031100 animal organ regeneration
GO:0031640 killing of cells of other organism
GO:0031727 CCR2 chemokine receptor binding
GO:0032570 response to progesterone
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033552 response to vitamin B3
GO:0035684 helper T cell extravasation
GO:0035690 cellular response to drug
GO:0035702 monocyte homeostasis
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043025 neuronal cell body
GO:0043200 response to amino acid
GO:0043204 perikaryon
GO:0043547 positive regulation of GTPase activity
GO:0043615 astrocyte cell migration
GO:0043679 axon terminus
GO:0044299 C-fiber
GO:0045202 synapse
GO:0045471 response to ethanol
GO:0045785 positive regulation of cell adhesion
GO:0046677 response to antibiotic
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048020 CCR chemokine receptor binding
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0048471 perinuclear region of cytoplasm
GO:0050806 positive regulation of synaptic transmission
GO:0050870 positive regulation of T cell activation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0060137 maternal process involved in parturition
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
GO:0071318 cellular response to ATP
GO:0071333 cellular response to glucose stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071392 cellular response to estradiol stimulus
GO:0071398 cellular response to fatty acid
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:0090303 positive regulation of wound healing
GO:0090314 positive regulation of protein targeting to membrane
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1905237 response to cyclosporin A
GO:2000427 positive regulation of apoptotic cell clearance

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000827 CC chemokine, conserved siteSiteConserved site
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CCL2_MOUSEACKR2_HUMANBioGRID9405404 details
CCL2_MOUSECCR2_MOUSEBioGRID8631787 8662823 details