Entity Details

Primary name BRCC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46736
EntryNameBRCC3_HUMAN
FullNameLys-63-specific deubiquitinase BRCC36
TaxID9606
Evidenceevidence at protein level
Length316
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesBRCC3

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0000922 spindle pole
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007049 cell cycle
GO:0008237 metallopeptidase activity
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0030234 enzyme regulator activity
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0045739 positive regulation of DNA repair
GO:0046872 metal ion binding
GO:0051301 cell division
GO:0070122 isopeptidase activity
GO:0070531 BRCA1-A complex
GO:0070536 protein K63-linked deubiquitination
GO:0070537 histone H2A K63-linked deubiquitination
GO:0070552 BRISC complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000555 JAB1/MPN/MOV34 metalloenzyme domainDomainDomain
IPR033860 Brcc36 isopeptidaseFamilyFamily
IPR037518 MPN domainDomainDomain
IPR040749 BRCC36, C-terminal helical domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink