Entity Details

Primary name NEDD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46934
EntryNameNEDD4_HUMAN
FullNameE3 ubiquitin-protein ligase NEDD4
TaxID9606
Evidenceevidence at protein level
Length1319
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNEDD4

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000785 chromatin
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006622 protein targeting to lysosome
GO:0007041 lysosomal transport
GO:0007528 neuromuscular junction development
GO:0010766 negative regulation of sodium ion transport
GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016241 regulation of macroautophagy
GO:0016327 apicolateral plasma membrane
GO:0016567 protein ubiquitination
GO:0019871 sodium channel inhibitor activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 neuron projection development
GO:0031623 receptor internalization
GO:0031698 beta-2 adrenergic receptor binding
GO:0032801 receptor catabolic process
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043197 dendritic spine
GO:0044111 formation of structure involved in a symbiotic process
GO:0045732 positive regulation of protein catabolic process
GO:0046755 viral budding
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048471 perinuclear region of cytoplasm
GO:0048814 regulation of dendrite morphogenesis
GO:0050807 regulation of synapse organization
GO:0050815 phosphoserine residue binding
GO:0050816 phosphothreonine residue binding
GO:0050847 progesterone receptor signaling pathway
GO:0051592 response to calcium ion
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070063 RNA polymerase binding
GO:0070064 proline-rich region binding
GO:0070534 protein K63-linked ubiquitination
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:2000650 negative regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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