Entity Details

Primary name IQGA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46940
EntryNameIQGA1_HUMAN
FullNameRas GTPase-activating-like protein IQGAP1
TaxID9606
Evidenceevidence at protein level
Length1657
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesIQGAP1

GO terms

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GOName
GO:0001726 ruffle
GO:0005078 MAP-kinase scaffold activity
GO:0005095 GTPase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0016032 viral process
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031267 small GTPase binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0032991 protein-containing complex
GO:0036057 slit diaphragm
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043005 neuron projection
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0044548 S100 protein binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045860 positive regulation of protein kinase activity
GO:0051015 actin filament binding
GO:0051019 mitogen-activated protein kinase binding
GO:0051894 positive regulation of focal adhesion assembly
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072015 glomerular visceral epithelial cell development
GO:1900006 positive regulation of dendrite development
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1903829 positive regulation of cellular protein localization
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990138 neuron projection extension
GO:1990776 response to angiotensin

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR000593 RasGAP protein, C-terminalDomainDomain
IPR001202 WW domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule

Interactions

3 interactions