Entity Details

Primary name BCL2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP10417
EntryNameBCL2_MOUSE
FullNameApoptosis regulator Bcl-2
TaxID10090
Evidenceevidence at protein level
Length236
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesBcl2

GO terms

Show/Hide Table
GOName
GO:0000209 protein polyubiquitination
GO:0000902 cell morphogenesis
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001952 regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002260 lymphocyte homeostasis
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002520 immune system development
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006874 cellular calcium ion homeostasis
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0007569 cell aging
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0009887 animal organ morphogenesis
GO:0010039 response to iron ion
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014031 mesenchymal cell development
GO:0014042 positive regulation of neuron maturation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015267 channel activity
GO:0016020 membrane
GO:0016248 channel inhibitor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019903 protein phosphatase binding
GO:0021747 cochlear nucleus development
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030061 mitochondrial crista
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031069 hair follicle morphogenesis
GO:0031103 axon regeneration
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031965 nuclear membrane
GO:0031966 mitochondrial membrane
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032848 negative regulation of cellular pH reduction
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035265 organ growth
GO:0040008 regulation of growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043067 regulation of programmed cell death
GO:0043085 positive regulation of catalytic activity
GO:0043209 myelin sheath
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043473 pigmentation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043583 ear development
GO:0044877 protein-containing complex binding
GO:0045069 regulation of viral genome replication
GO:0045471 response to ethanol
GO:0045636 positive regulation of melanocyte differentiation
GO:0045930 negative regulation of mitotic cell cycle
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048041 focal adhesion assembly
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048087 positive regulation of developmental pigmentation
GO:0048471 perinuclear region of cytoplasm
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048589 developmental growth
GO:0048599 oocyte development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048753 pigment granule organization
GO:0048873 homeostasis of number of cells within a tissue
GO:0050790 regulation of catalytic activity
GO:0050853 B cell receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051400 BH domain binding
GO:0051402 neuron apoptotic process
GO:0051434 BH3 domain binding
GO:0051607 defense response to virus
GO:0051721 protein phosphatase 2A binding
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0051924 regulation of calcium ion transport
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 cellular response to organic substance
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098609 cell-cell adhesion
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Mitochondrion outer membrane
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4DomainDomain
IPR004725 Apoptosis regulator, Bcl-2/ BclXFamilyFamily
IPR013278 Apoptosis regulator, Bcl-2FamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
BCL2_MOUSEPP1A_MOUSEBioGRID, IntAct17274640 details
BCL2_MOUSEPP1G_MOUSEBioGRID, IntAct17274640 details
BCL2_MOUSEBAX_MOUSEBioGRID, IntAct, MINT16839884 20621101 8631771 9115213 details
BCL2_MOUSEB2L11_MOUSEBioGRID, IntAct, MINT15136728 17289999 21151042 23840878 details
BCL2_MOUSEBAD_MOUSEBioGRID, IntAct16839884 21084607 details
BCL2_MOUSEGIMA3_MOUSEDIP16509771 details
BCL2_MOUSEGIMA5_MOUSEDIP16509771 details
BCL2_MOUSEPAXI_HUMANBioGRID10417825 details
BCL2_MOUSEBAG3_MOUSEBioGRID11527400 details
BCL2_MOUSEBAG4_MOUSEBioGRID11527400 details
BCL2_MOUSECDK2_MOUSEBioGRID16102793 details
BCL2_MOUSECPT1A_MOUSEBioGRID9070836 details
BCL2_MOUSEBID_MOUSEMINT11583631 details
BCL2_MOUSEBAK_MOUSEIntAct12881569 details
BCL2_MOUSEBECN1_MOUSEBioGRID, DIP, UniProt18281291 18772134 20819940 22258505 28347844 29849149 details
BCL2_MOUSEFAK1_MOUSEBioGRID10417825 details
BCL2_MOUSEPRKN_MOUSEBioGRID20889974 details
BCL2_MOUSEBAG1_MOUSEBioGRID7834747 details
BCL2_MOUSERAD9A_MOUSEBioGRID12628935 15983387 details
BCL2_MOUSEPP2BA_MOUSEBioGRID12617961 details
BCL2_MOUSEMYC_MOUSEBioGRID17382917 details
BCL2_MOUSECANB1_MOUSEBioGRID16717086 details
BCL2_MOUSEPP2AA_MOUSEBioGRID16717086 details
BCL2_MOUSEVA0D2_MOUSEBioGRID16717086 details
BCL2_MOUSEACTZ_MOUSEBioGRID16717086 details
BCL2_MOUSESNAA_MOUSEBioGRID16717086 details
BCL2_MOUSESNAG_MOUSEBioGRID16717086 details
BCL2_MOUSESNG1_MOUSEBioGRID16717086 details
BCL2_MOUSEPAXI_MOUSEBioGRID14699151 details
BCL2_MOUSEBNIP3_MOUSEBioGRID18281291 details
BCL2_MOUSETCAM1_MOUSEBioGRID18772134 details
BCL2_MOUSEMYD88_MOUSEBioGRID18772134 details
BCL2_MOUSEP53_MOUSEBioGRID30683842 details