Entity Details

Primary name SOX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48431
EntryNameSOX2_HUMAN
FullNameTranscription factor SOX-2
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSOX2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001714 endodermal cell fate specification
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0010468 regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0021781 glial cell fate commitment
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0042246 tissue regeneration
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0070848 response to growth factor
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR022097 Transcription factor SOXFamilyFamily
IPR032643 Transcription factor SOX-2FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SOX2_HUMANCBX5_MOUSEBioGRID31077711 details
SOX2_HUMANCBX1_MOUSEBioGRID31077711 details