Entity Details

Primary name RXRG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48443
EntryNameRXRG_HUMAN
FullNameRetinoic acid receptor RXR-gamma
TaxID9606
Evidenceevidence at protein level
Length463
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesRXRG

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0030154 cell differentiation
GO:0032526 response to retinoic acid
GO:0044323 retinoic acid-responsive element binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048384 retinoic acid receptor signaling pathway
GO:0048856 anatomical structure development
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000003 Retinoid X receptor/HNF4FamilyFamily
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021780 Nuclear/hormone receptor activator site AF-1DomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00307 BexaroteneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
RXRG_HUMANNR0B2_MOUSEBioGRID8650544 details
RXRG_HUMANAJUBA_MOUSEDIP20133701 details