Entity Details

Primary name KC1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48729
EntryNameKC1A_HUMAN
FullNameCasein kinase I isoform alpha
TaxID9606
Evidenceevidence at protein level
Length337
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCSNK1A1

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005929 cilium
GO:0006468 protein phosphorylation
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0030877 beta-catenin destruction complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0036064 ciliary basal body
GO:0045104 intermediate filament cytoskeleton organization
GO:0051301 cell division
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904424 regulation of GTP binding
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KC1A_HUMANCAR11_MOUSEBioGRID19118383 details