Entity Details

Primary name MTR1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49286
EntryNameMTR1B_HUMAN
FullNameMelatonin receptor type 1B
TaxID9606
Evidenceevidence at protein level
Length362
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesMTNR1B

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0008502 melatonin receptor activity
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0042593 glucose homeostasis
GO:0043010 camera-type eye development
GO:0043524 negative regulation of neuron apoptotic process
GO:0045202 synapse
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046676 negative regulation of insulin secretion
GO:0050796 regulation of insulin secretion
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051970 negative regulation of transmission of nerve impulse
GO:0051971 positive regulation of transmission of nerve impulse
GO:0098908 regulation of neuronal action potential
GO:1902260 negative regulation of delayed rectifier potassium channel activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000025 Melatonin receptor familyFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002278 Melatonin receptor 1A/1BFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00980 RamelteonDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB06594 AgomelatineDrugbanksmall molecule
DB09071 TasimelteonDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
MTR1B_HUMANDUS3_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANDESP_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANMYO1G_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANAT1A3_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANDPYL2_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANKPCZ_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANTBB5_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANPP2BA_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANRBGPR_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANTBA1C_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANCRYM_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANKPCG_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANPYGB_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANTBB3_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANCOF1_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMAN5HT3B_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANHS105_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANFBXL7_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANGMFB_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANTBB4A_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANITB4_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANGRP75_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANCTND1_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANROCK2_MOUSEBioGRID, IntAct26514267 details
MTR1B_HUMANPTN13_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANMTAP2_MOUSEBioGRID, IntAct18448421 26514267 details
MTR1B_HUMANSTXB1_MOUSEBioGRID26514267 details
MTR1B_HUMANCAC1B_MOUSEBioGRID26514267 details
MTR1B_HUMANSCNAA_MOUSEBioGRID26514267 details
MTR1B_HUMANMK10_MOUSEBioGRID26514267 details
MTR1B_HUMANPP2AB_MOUSEBioGRID18448421 details
MTR1B_HUMANSTXB3_MOUSEIntAct26514267 details
MTR1B_HUMANSNP25_MOUSEIntAct26514267 details