Entity Details

Primary name CTCF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49711
EntryNameCTCF_HUMAN
FullNameTranscriptional repressor CTCF
TaxID9606
Evidenceevidence at protein level
Length727
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCTCF

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 transcription coregulator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006306 DNA methylation
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007059 chromosome segregation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010216 maintenance of DNA methylation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016584 nucleosome positioning
GO:0031060 regulation of histone methylation
GO:0035065 regulation of histone acetylation
GO:0040029 regulation of gene expression, epigenetic
GO:0040030 regulation of molecular function, epigenetic
GO:0043035 chromatin insulator sequence binding
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071459 protein localization to chromosome, centromeric region
GO:0071514 genetic imprinting

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CTCF_HUMANPO5F1_MOUSEDIP19536159 details
CTCF_HUMANTAF3_MOUSEIntAct21884934 details