Entity Details

Primary name NUMB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49757
EntryNameNUMB_HUMAN
FullNameProtein numb homolog
TaxID9606
Evidenceevidence at protein level
Length651
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNUMB

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0007409 axonogenesis
GO:0008013 beta-catenin binding
GO:0010008 endosome membrane
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0021670 lateral ventricle development
GO:0021849 neuroblast division in subventricular zone
GO:0030136 clathrin-coated vesicle
GO:0030335 positive regulation of cell migration
GO:0034332 adherens junction organization
GO:0045177 apical part of cell
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0050769 positive regulation of neurogenesis
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1903077 negative regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR006020 PTB/PI domainDomainDomain
IPR010449 NUMB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016698 Numb/numb-likeFamilyFamily

Diseases

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