Entity Details

Primary name GSK3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49840
EntryNameGSK3A_HUMAN
FullNameGlycogen synthase kinase-3 alpha
TaxID9606
Evidenceevidence at protein level
Length483
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesGSK3A

GO terms

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GOName
GO:0003073 regulation of systemic arterial blood pressure
GO:0003214 cardiac left ventricle morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007212 dopamine receptor signaling pathway
GO:0007399 nervous system development
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010905 negative regulation of UDP-glucose catabolic process
GO:0010975 regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030424 axon
GO:0030877 beta-catenin destruction complex
GO:0031398 positive regulation of protein ubiquitination
GO:0032007 negative regulation of TOR signaling
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034236 protein kinase A catalytic subunit binding
GO:0036016 cellular response to interleukin-3
GO:0036498 IRE1-mediated unfolded protein response
GO:0043025 neuronal cell body
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0044027 hypermethylation of CpG island
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045823 positive regulation of heart contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0060079 excitatory postsynaptic potential
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0071285 cellular response to lithium ion
GO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097440 apical dendrite
GO:0098794 postsynapse
GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902004 positive regulation of amyloid-beta formation
GO:1903146 regulation of autophagy of mitochondrion
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
GO:1990635 proximal dendrite
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000171 negative regulation of dendrite development
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR039192 Glycogen synthase kinase 3, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule