Entity Details

Primary name GSK3B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49841
EntryNameGSK3B_HUMAN
FullNameGlycogen synthase kinase-3 beta
TaxID9606
Evidenceevidence at protein level
Length420
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesGSK3B

GO terms

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GOName
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
GO:0006983 ER overload response
GO:0007165 signal transduction
GO:0007212 dopamine receptor signaling pathway
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008286 insulin receptor signaling pathway
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0010975 regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019082 viral protein processing
GO:0019901 protein kinase binding
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0030011 maintenance of cell polarity
GO:0030424 axon
GO:0030425 dendrite
GO:0030516 regulation of axon extension
GO:0030877 beta-catenin destruction complex
GO:0031175 neuron projection development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032886 regulation of microtubule-based process
GO:0034236 protein kinase A catalytic subunit binding
GO:0034452 dynactin binding
GO:0035556 intracellular signal transduction
GO:0036016 cellular response to interleukin-3
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0048156 tau protein binding
GO:0048814 regulation of dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050770 regulation of axonogenesis
GO:0051059 NF-kappaB binding
GO:0060079 excitatory postsynaptic potential
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071109 superior temporal gyrus development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0106027 neuron projection organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150101 regulation of microtubule anchoring at centrosome
GO:1900034 regulation of cellular response to heat
GO:1900181 negative regulation of protein localization to nucleus
GO:1900271 regulation of long-term synaptic potentiation
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904339 negative regulation of dopaminergic neuron differentiation
GO:1904646 cellular response to amyloid-beta
GO:1904781 positive regulation of protein localization to centrosome
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:1990909 Wnt signalosome
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000466 negative regulation of glycogen (starch) synthase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033573 Glycogen synthase kinase-3 betaFamilyFamily
IPR039192 Glycogen synthase kinase 3, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01356 Lithium cationDrugbanksmall molecule
DB01772 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-DioneDrugbanksmall molecule
DB01793 SB-409513Drugbanksmall molecule
DB01950 AR-AO-14418Drugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB02052 Indirubin-3'-monoximeDrugbanksmall molecule
DB03444 6-bromoindirubin-3'-oximeDrugbanksmall molecule
DB04014 AlsterpaulloneDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB07014 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazoleDrugbanksmall molecule
DB07058 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thioneDrugbanksmall molecule
DB07149 (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneDrugbanksmall molecule
DB07584 N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineDrugbanksmall molecule
DB07585 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridineDrugbanksmall molecule
DB07676 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-oneDrugbanksmall molecule
DB07812 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideDrugbanksmall molecule
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDrugbanksmall molecule
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDrugbanksmall molecule
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12129 TideglusibDrugbanksmall molecule
DB14507 Lithium citrateDrugbanksmall molecule
DB14508 Lithium succinateDrugbanksmall molecule
DB14509 Lithium carbonateDrugbanksmall molecule