Entity Details

Primary name GUAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49915
EntryNameGUAA_HUMAN
FullNameGMP synthase [glutamine-hydrolyzing]
TaxID9606
Evidenceevidence at protein level
Length693
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesGMPS

GO terms

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GOName
GO:0003921 GMP synthase activity
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006177 GMP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0016462 pyrophosphatase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001674 GMP synthase, C-terminalDomainDomain
IPR004739 GMP synthase, glutamine amidotransferaseDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR017926 Glutamine amidotransferaseDomainDomain
IPR022310 NAD/GMP synthaseDomainDomain
IPR025777 GMP synthetase ATP pyrophosphatase domainDomainDomain
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink