Entity Details

Primary name MRE11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49959
EntryNameMRE11_HUMAN
FullNameDouble-strand break repair protein MRE11
TaxID9606
Evidenceevidence at protein level
Length708
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMRE11

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000019 regulation of mitotic recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0003690 double-stranded DNA binding
GO:0004518 nuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007129 homologous chromosome pairing at meiosis
GO:0007131 reciprocal meiotic recombination
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016032 viral process
GO:0016605 PML body
GO:0030145 manganese ion binding
GO:0030870 Mre11 complex
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042138 meiotic DNA double-strand break formation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045296 cadherin binding
GO:0097552 mitochondrial double-strand break repair via homologous recombination
GO:0110025 DNA strand resection involved in replication fork processing
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR003701 DNA double-strand break repair protein Mre11FamilyFamily
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR007281 Mre11, DNA-bindingDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR038487 Mre11, capping domainFamilyHomologous superfamily
IPR041796 Mre11 nuclease, N-terminal metallophosphatase domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MRE11_HUMANPIHD1_MOUSEDIP24794838 details
MRE11_HUMANZN365_MOUSEIntAct23966166 details