Entity Details

Primary name PERF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP10820
EntryNamePERF_MOUSE
FullNamePerforin-1
TaxID10090
Evidenceevidence at protein level
Length554
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPrf1

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001913 T cell mediated cytotoxicity
GO:0002357 defense response to tumor cell
GO:0002418 immune response to tumor cell
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0007623 circadian rhythm
GO:0016021 integral component of membrane
GO:0019835 cytolysis
GO:0022829 wide pore channel activity
GO:0031410 cytoplasmic vesicle
GO:0031904 endosome lumen
GO:0042802 identical protein binding
GO:0044194 cytolytic granule
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism

Subcellular Location

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Subcellular Location
Cell membrane
Cytolytic granule
Endosome lumen
Secreted

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR020863 Membrane attack complex component/perforin domain, conserved siteSiteConserved site
IPR020864 Membrane attack complex component/perforin (MACPF) domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037300 Perforin-1, C2 domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PERF_MOUSEPERF_MOUSEDIP21037563 details