Entity Details

Primary name 5HT6R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50406
EntryName5HT6R_HUMAN
FullName5-hydroxytryptamine receptor 6
TaxID9606
Evidenceevidence at protein level
Length440
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHTR6

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0021795 cerebral cortex cell migration
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0032008 positive regulation of TOR signaling
GO:0045202 synapse

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002232 5-Hydroxytryptamine 6 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01488 DimethyltryptamineDrugbanksmall molecule
DB04829 Lysergic acid diethylamideDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05042 SGS518Drugbanksmall molecule
DB05993 PRX-07034Drugbanksmall molecule
DB06140 SUVN-502Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
5HT6R_HUMANNOVA1_MOUSEUniProt30853821 details
5HT6R_HUMANMAP1B_MOUSEIntAct24614691 details