Entity Details

Primary name SMCA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51532
EntryNameSMCA4_HUMAN
FullNameTranscription activator BRG1
TaxID9606
Evidenceevidence at protein level
Length1647
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSMARCA4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001188 RNA polymerase I preinitiation complex assembly
GO:0002039 p53 binding
GO:0003407 neural retina development
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006325 chromatin organization
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0008094 ATPase, acting on DNA
GO:0008134 transcription factor binding
GO:0016020 membrane
GO:0016514 SWI/SNF complex
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030957 Tat protein binding
GO:0032991 protein-containing complex
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043044 ATP-dependent chromatin remodeling
GO:0043923 positive regulation by host of viral transcription
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0050681 androgen receptor binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070182 DNA polymerase binding
GO:0070577 lysine-acetylated histone binding
GO:0070615 nucleosome-dependent ATPase activity
GO:0071564 npBAF complex
GO:0071565 nBAF complex
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1902661 positive regulation of glucose mediated signaling pathway
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904837 beta-catenin-TCF complex assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR001487 BromodomainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR006576 BRK domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014012 Helicase/SANT-associated domainDomainDomain
IPR014978 Glutamine-Leucine-Glutamine, QLQDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029295 Snf2, ATP coupling domainDomainDomain
IPR030100 SWI/SNF complex subunit BRG1FamilyFamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037259 BRK domain superfamilyFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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