Entity Details

Primary name IRAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51617
EntryNameIRAK1_HUMAN
FullNameInterleukin-1 receptor-associated kinase 1
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesIRAK1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0007568 aging
GO:0010008 endosome membrane
GO:0016032 viral process
GO:0016301 kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031072 heat shock protein binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071456 cellular response to hypoxia
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Nucleus

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR035533 Interleukin-1 receptor-associated kinase 1, death domainDomainDomain
IPR035536 Interleukin-1 receptor-associated kinase 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule