Entity Details

Primary name NEK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51955
EntryNameNEK2_HUMAN
FullNameSerine/threonine-protein kinase Nek2
TaxID9606
Evidenceevidence at protein level
Length445
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNEK2

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001824 blastocyst development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0007088 regulation of mitotic nuclear division
GO:0007096 regulation of exit from mitosis
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019903 protein phosphatase binding
GO:0030496 midbody
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032991 protein-containing complex
GO:0043392 negative regulation of DNA binding
GO:0046602 regulation of mitotic centrosome separation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0051225 spindle assembly
GO:0051299 centrosome separation
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051973 positive regulation of telomerase activity
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0090307 mitotic spindle assembly
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903126 negative regulation of centriole-centriole cohesion
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07180 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink