Entity Details

Primary name PARP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP11103
EntryNamePARP1_MOUSE
FullNamePoly [ADP-ribose] polymerase 1
TaxID10090
Evidenceevidence at protein level
Length1013
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006471 protein ADP-ribosylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007005 mitochondrion organization
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010990 regulation of SMAD protein complex assembly
GO:0016540 protein autoprocessing
GO:0016604 nuclear body
GO:0018312 peptidyl-serine ADP-ribosylation
GO:0018424 peptidyl-glutamic acid poly-ADP-ribosylation
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030331 estrogen receptor binding
GO:0030592 DNA ADP-ribosylation
GO:0032042 mitochondrial DNA metabolic process
GO:0032700 negative regulation of interleukin-17 production
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0035861 site of double-strand break
GO:0036211 protein modification process
GO:0040009 regulation of growth rate
GO:0042769 DNA damage response, detection of DNA damage
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043504 mitochondrial DNA repair
GO:0044030 regulation of DNA methylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0047485 protein N-terminus binding
GO:0048148 behavioral response to cocaine
GO:0050790 regulation of catalytic activity
GO:0050882 voluntary musculoskeletal movement
GO:0051287 NAD binding
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0070412 R-SMAD binding
GO:0071451 cellular response to superoxide
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090734 site of DNA damage
GO:0140294 NAD DNA ADP-ribosyltransferase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901216 positive regulation of neuron death
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903516 regulation of single strand break repair
GO:1903518 positive regulation of single strand break repair
GO:1903827 regulation of cellular protein localization
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:1904646 cellular response to amyloid-beta
GO:1904762 positive regulation of myofibroblast differentiation
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:1990404 protein ADP-ribosylase activity
GO:1990966 ATP generation from poly-ADP-D-ribose
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001170 negative regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR001510 Zinc finger, PARP-typeDomainDomain
IPR004102 Poly(ADP-ribose) polymerase, regulatory domainDomainDomain
IPR008288 Poly [ADP-ribose] polymeraseFamilyFamily
IPR008893 WGR domainDomainDomain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domainDomainDomain
IPR012982 PADR1 domainDomainDomain
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamilyFamilyHomologous superfamily
IPR036930 WGR domain superfamilyFamilyHomologous superfamily
IPR036957 Zinc finger, PARP-type superfamilyFamilyHomologous superfamily
IPR038650 PADR1 domain superfamilyFamilyHomologous superfamily

Diseases

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