Entity Details

Primary name MP2K6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52564
EntryNameMP2K6_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 6
TaxID9606
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K6

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0002931 response to ischemia
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0006975 DNA damage induced protein phosphorylation
GO:0007165 signal transduction
GO:0019901 protein kinase binding
GO:0022602 ovulation cycle process
GO:0032308 positive regulation of prostaglandin secretion
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0072709 cellular response to sorbitol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MP2K6_HUMANMK14_MOUSEBioGRID11062068 details