Entity Details

Primary name VAV2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52735
EntryNameVAV2_HUMAN
FullNameGuanine nucleotide exchange factor VAV2
TaxID9606
Evidenceevidence at protein level
Length878
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesVAV2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR035732 VAV2 protein, second SH3 domainDomainDomain
IPR035733 VAV2 protein, first SH3 domainDomainDomain
IPR035880 VAV2, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
VAV2_HUMANMBP_MOUSEBioGRID, MINT18067320 details