Entity Details

Primary name TPA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP11214
EntryNameTPA_MOUSE
FullNameTissue-type plasminogen activator
TaxID10090
Evidenceevidence at protein level
Length559
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPlat

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006508 proteolysis
GO:0009986 cell surface
GO:0014909 smooth muscle cell migration
GO:0030141 secretory granule
GO:0031639 plasminogen activation
GO:0035249 synaptic transmission, glutamatergic
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0045861 negative regulation of proteolysis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051219 phosphoprotein binding
GO:0060279 positive regulation of ovulation
GO:0060468 prevention of polyspermy
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0098992 neuronal dense core vesicle
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:0099544 perisynaptic space

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000083 Fibronectin, type IDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR026280 Tissue plasminogen activatorFamilyFamily
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR034811 Tissue-type plasminogen activatorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Interactions

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