Entity Details

Primary name PPP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53041
EntryNamePPP5_HUMAN
FullNameSerine/threonine-protein phosphatase 5
TaxID9606
Evidenceevidence at protein level
Length499
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPP5C

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000278 mitotic cell cycle
GO:0001933 negative regulation of protein phosphorylation
GO:0001965 G-protein alpha-subunit binding
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0008017 microtubule binding
GO:0008289 lipid binding
GO:0010288 response to lead ion
GO:0016576 histone dephosphorylation
GO:0016791 phosphatase activity
GO:0032991 protein-containing complex
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0043278 response to morphine
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0051879 Hsp90 protein binding
GO:0070262 peptidyl-serine dephosphorylation
GO:0070301 cellular response to hydrogen peroxide
GO:0071276 cellular response to cadmium ion
GO:0101031 chaperone complex
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1901215 negative regulation of neuron death
GO:1904550 response to arachidonic acid
GO:1990635 proximal dendrite
GO:2000324 positive regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001440 Tetratricopeptide repeat 1RepeatRepeat
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR011236 Serine/threonine protein phosphatase 5FamilyFamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013235 PPP domainDomainDomain
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041753 PP5, C-terminal metallophosphatase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PPP5_HUMANCHRD1_MOUSEBioGRID23184943 details
PPP5_HUMANITBP2_MOUSEBioGRID23184943 details