Entity Details

Primary name PLK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53350
EntryNamePLK1_HUMAN
FullNameSerine/threonine-protein kinase PLK1
TaxID9606
Evidenceevidence at protein level
Length603
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPLK1

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0000287 magnesium ion binding
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000795 synaptonemal complex
GO:0000922 spindle pole
GO:0001578 microtubule bundle formation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007052 mitotic spindle organization
GO:0007062 sister chromatid cohesion
GO:0007076 mitotic chromosome condensation
GO:0007077 mitotic nuclear membrane disassembly
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007098 centrosome cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008017 microtubule binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010997 anaphase-promoting complex binding
GO:0015630 microtubule cytoskeleton
GO:0016321 female meiosis chromosome segregation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0030496 midbody
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0034451 centriolar satellite
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043393 regulation of protein binding
GO:0045143 homologous chromosome segregation
GO:0045184 establishment of protein localization
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 positive regulation of proteolysis
GO:0051081 nuclear membrane disassembly
GO:0051233 spindle midzone
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051726 regulation of cell cycle
GO:0070194 synaptonemal complex disassembly
GO:0071168 protein localization to chromatin
GO:0090435 protein localization to nuclear envelope
GO:0097431 mitotic spindle pole
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901673 regulation of mitotic spindle assembly
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904776 regulation of protein localization to cell cortex

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033695 Second polo-box domainDomainDomain
IPR033701 First polo-box domainDomainDomain
IPR033702 Polo-like kinase 1, catalytic domainDomainDomain
IPR036947 POLO box domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06897 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-olDrugbanksmall molecule
DB06963 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamideDrugbanksmall molecule
DB07186 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDEDrugbanksmall molecule
DB07789 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]ureaDrugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule