Entity Details

Primary name DAPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53355
EntryNameDAPK1_HUMAN
FullNameDeath-associated protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length1430
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDAPK1

GO terms

Show/Hide Table
GOName
GO:0002357 defense response to tumor cell
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0015629 actin cytoskeleton
GO:0017075 syntaxin-1 binding
GO:0017148 negative regulation of translation
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046777 protein autophosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0071447 cellular response to hydroperoxide
GO:0097190 apoptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020676 Death-associated protein kinase 1FamilyFamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR020859 Roc domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB04069 5,6-Dihydro-Benzo[H]Cinnolin-3-YlamineDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB07444 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DAPK1_HUMANMIB1_MOUSEBioGRID12351649 details