Entity Details

Primary name PMS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54278
EntryNamePMS2_HUMAN
FullNameMismatch repair endonuclease PMS2
TaxID9606
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPMS2

GO terms

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GOName
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006298 mismatch repair
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016887 ATP hydrolysis activity
GO:0032138 single base insertion or deletion binding
GO:0032300 mismatch repair complex
GO:0032389 MutLalpha complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042493 response to drug

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002099 DNA mismatch repair protein family, N-terminalDomainDomain
IPR013507 DNA mismatch repair protein, S5 domain 2-likeDomainDomain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR014762 DNA mismatch repair, conserved siteSiteConserved site
IPR014790 MutL, C-terminal, dimerisationDomainDomain
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR037198 MutL, C-terminal domain superfamilyFamilyHomologous superfamily
IPR038973 DNA mismatch repair protein MutL/Mlh/PmsFamilyFamily
IPR042120 MutL, C-terminal domain, dimerisation subdomainFamilyHomologous superfamily
IPR042121 MutL, C-terminal domain, regulatory subdomainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02930 Adenosine 5'-[gamma-thio]triphosphateDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink