Entity Details

Primary name AAPK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54646
EntryNameAAPK2_HUMAN
FullName5'-AMP-activated protein kinase catalytic subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length552
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPRKAA2

GO terms

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GOName
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006853 carnitine shuttle
GO:0007165 signal transduction
GO:0008610 lipid biosynthetic process
GO:0010494 cytoplasmic stress granule
GO:0010508 positive regulation of autophagy
GO:0010629 negative regulation of gene expression
GO:0014850 response to muscle activity
GO:0016055 Wnt signaling pathway
GO:0016236 macroautophagy
GO:0016239 positive regulation of macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016607 nuclear speck
GO:0030424 axon
GO:0030425 dendrite
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0034599 cellular response to oxidative stress
GO:0035174 histone serine kinase activity
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0042149 cellular response to glucose starvation
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0045821 positive regulation of glycolytic process
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 rhythmic process
GO:0050405 [acetyl-CoA carboxylase] kinase activity
GO:0055089 fatty acid homeostasis
GO:0062028 regulation of stress granule assembly
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071277 cellular response to calcium ion
GO:0071333 cellular response to glucose stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903829 positive regulation of cellular protein localization
GO:1904428 negative regulation of tubulin deacetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR028783 PRKAA2, UBA-like autoinhibitory domainDomainDomain
IPR032270 AMPK, C-terminal adenylate sensor domainDomainDomain
IPR039148 5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions