Entity Details

Primary name RARA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP11416
EntryNameRARA_MOUSE
FullNameRetinoic acid receptor alpha
TaxID10090
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesRara

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001657 ureteric bud development
GO:0001843 neural tube closure
GO:0001889 liver development
GO:0001972 retinoic acid binding
GO:0002068 glandular epithelial cell development
GO:0003148 outflow tract septum morphogenesis
GO:0003417 growth plate cartilage development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007565 female pregnancy
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0017148 negative regulation of translation
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0021766 hippocampus development
GO:0030154 cell differentiation
GO:0030425 dendrite
GO:0030850 prostate gland development
GO:0030852 regulation of granulocyte differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0031076 embryonic camera-type eye development
GO:0031490 chromatin DNA binding
GO:0031641 regulation of myelination
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032991 protein-containing complex
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0035264 multicellular organism growth
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043422 protein kinase B binding
GO:0043565 sequence-specific DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0045471 response to ethanol
GO:0045596 negative regulation of cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045947 negative regulation of translational initiation
GO:0048027 mRNA 5'-UTR binding
GO:0048167 regulation of synaptic plasticity
GO:0048384 retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051018 protein kinase A binding
GO:0051099 positive regulation of binding
GO:0051393 alpha-actinin binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060010 Sertoli cell fate commitment
GO:0060173 limb development
GO:0060324 face development
GO:0060348 bone development
GO:0060534 trachea cartilage development
GO:0060591 chondroblast differentiation
GO:0061037 negative regulation of cartilage development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071391 cellular response to estrogen stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003078 Retinoic acid receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
RARA_MOUSETIF1A_MOUSEIntAct8978696 details
RARA_MOUSEKS6A5_MOUSEMINT19078967 details
RARA_MOUSEDDR1_MOUSEMINT19078967 details
RARA_MOUSENF2L2_HUMANMINT28777872 details
RARA_MOUSENRIP1_HUMANBioGRID12403842 details
RARA_MOUSENCOA1_MOUSEBioGRID8855229 details
RARA_MOUSENRIP1_MOUSEBioGRID17389641 20211142 details
RARA_MOUSEELOB_MOUSEBioGRID9869640 details
RARA_MOUSEELOC_MOUSEBioGRID9869640 details
RARA_MOUSECDK1_HUMANBioGRID10383391 details
RARA_MOUSEMK03_HUMANBioGRID10383391 details
RARA_MOUSEMK08_HUMANBioGRID10383391 details
RARA_MOUSEMK09_HUMANBioGRID10383391 details
RARA_MOUSEMK10_HUMANBioGRID10383391 details
RARA_MOUSEMED25_MOUSEMINT17641689 details
RARA_MOUSEFLOT2_MOUSEI2D22056876 details
RARA_MOUSEGNAQ_MOUSEI2D22056876 details
RARA_MOUSECTNB1_MOUSEIntAct24074870 details
RARA_MOUSEAJUBA_MOUSEDIP20133701 details
RARA_MOUSETACC1_HUMANIntAct20078863 details
RARA_MOUSETACC1_MOUSEIntAct20078863 details
RARA_MOUSEGRIP1_MOUSEBioGRID17389641 details
RARA_MOUSEKAT2B_MOUSEBioGRID17389641 details
RARA_MOUSETGIF1_MOUSEBioGRID16428452 details
RARA_MOUSENRIP2_MOUSEBioGRID10860982 details
RARA_MOUSEPURA_MOUSEBioGRID18495661 details
RARA_MOUSEPABP1_MOUSEBioGRID18495661 details
RARA_MOUSESFPQ_MOUSEBioGRID18495661 details
RARA_MOUSENONO_MOUSEBioGRID18495661 details
RARA_MOUSEHNRPU_MOUSEBioGRID18495661 details
RARA_MOUSE1433Z_MOUSEBioGRID18495661 details
RARA_MOUSEPURB_MOUSEBioGRID18495661 details
RARA_MOUSENR1H4_MOUSEBioGRID18495661 details
RARA_MOUSETHOC4_MOUSEBioGRID18495661 details
RARA_MOUSEEIF3A_MOUSEBioGRID18495661 details
RARA_MOUSEEIF3B_MOUSEBioGRID18495661 details
RARA_MOUSERS3_MOUSEBioGRID18495661 details
RARA_MOUSERS4X_MOUSEBioGRID18495661 details
RARA_MOUSERS5_MOUSEBioGRID18495661 details
RARA_MOUSERS6_MOUSEBioGRID18495661 details
RARA_MOUSERS13_MOUSEBioGRID18495661 details
RARA_MOUSERS16_MOUSEBioGRID18495661 details
RARA_MOUSERS17_MOUSEBioGRID18495661 details
RARA_MOUSERS19_MOUSEBioGRID18495661 details
RARA_MOUSERS25_MOUSEBioGRID18495661 details
RARA_MOUSERS26_MOUSEBioGRID18495661 details
RARA_MOUSERL23_MOUSEBioGRID18495661 details
RARA_MOUSERSSA_MOUSEBioGRID18495661 details
RARA_MOUSEHS71B_MOUSEBioGRID18495661 details
RARA_MOUSEDDX1_MOUSEBioGRID18495661 details
RARA_MOUSEDDX3X_MOUSEBioGRID18495661 details
RARA_MOUSEROAA_MOUSEBioGRID18495661 details
RARA_MOUSEHNRPD_MOUSEBioGRID18495661 details
RARA_MOUSEHNRPQ_MOUSEBioGRID18495661 details
RARA_MOUSEEWS_MOUSEBioGRID18495661 details
RARA_MOUSEFUS_MOUSEBioGRID18495661 details
RARA_MOUSERBM3_MOUSEBioGRID18495661 details
RARA_MOUSEG3BP1_MOUSEBioGRID18495661 details
RARA_MOUSESOSB1_MOUSEBioGRID18495661 details
RARA_MOUSEAP2A1_MOUSEBioGRID18495661 details
RARA_MOUSEAP2A2_MOUSEBioGRID18495661 details
RARA_MOUSEAP2B1_MOUSEBioGRID18495661 details
RARA_MOUSEAP2M1_MOUSEBioGRID18495661 details
RARA_MOUSEVIME_MOUSEBioGRID18495661 details
RARA_MOUSEDESM_MOUSEBioGRID18495661 details
RARA_MOUSETBA3_MOUSEBioGRID18495661 details
RARA_MOUSEACTB_MOUSEBioGRID18495661 details
RARA_MOUSETMOD1_MOUSEBioGRID18495661 32325033 details
RARA_MOUSETERA_MOUSEBioGRID18495661 details
RARA_MOUSE1433B_MOUSEBioGRID18495661 details
RARA_MOUSE1433G_MOUSEBioGRID18495661 details
RARA_MOUSEKCND2_MOUSEBioGRID18495661 details
RARA_MOUSESND1_MOUSEBioGRID18495661 details
RARA_MOUSENDKA_MOUSEBioGRID18495661 details
RARA_MOUSEEP300_MOUSEBioGRID21722948 details
RARA_MOUSESMRD3_MOUSEBioGRID17363140 details
RARA_MOUSEARI1A_MOUSEBioGRID17363140 details
RARA_MOUSETRIB3_MOUSEBioGRID28486108 details