Entity Details

Primary name NR1H2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55055
EntryNameNR1H2_HUMAN
FullNameOxysterols receptor LXR-beta
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNR1H2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010884 positive regulation of lipid storage
GO:0010887 negative regulation of cholesterol storage
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031667 response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0034191 apolipoprotein A-I receptor binding
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0042632 cholesterol homeostasis
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048550 negative regulation of pinocytosis
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051117 ATPase binding
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090187 positive regulation of pancreatic juice secretion
GO:0090340 positive regulation of secretion of lysosomal enzymes
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1903573 negative regulation of response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR023257 Liver X receptorFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03791 GW-3965Drugbanksmall molecule
DB03848 Benzenesulfinic acidDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07082 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OLDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB13174 RheinDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NR1H2_HUMANSENP3_MOUSEDIP21331046 details
NR1H2_HUMANCOR2A_MOUSEDIP21331046 details