Entity Details

Primary name AFAD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55196
EntryNameAFAD_HUMAN
FullNameAfadin
TaxID9606
Evidenceevidence at protein level
Length1824
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesAFDN

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008022 protein C-terminus binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0022409 positive regulation of cell-cell adhesion
GO:0030054 cell junction
GO:0030336 negative regulation of cell migration
GO:0031267 small GTPase binding
GO:0032880 regulation of protein localization
GO:0034332 adherens junction organization
GO:0043547 positive regulation of GTPase activity
GO:0044291 cell-cell contact zone
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0045296 cadherin binding
GO:0046930 pore complex
GO:0046931 pore complex assembly
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0061951 establishment of protein localization to plasma membrane
GO:0070160 tight junction
GO:0070830 bicellular tight junction assembly
GO:0090557 establishment of endothelial intestinal barrier
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell junction

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR002710 Dilute domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR037977 Afadin, cargo binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08574 (5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-oneDrugbanksmall molecule

Interactions

3 interactions