Entity Details

Primary name SYMC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56192
EntryNameSYMC_HUMAN
FullNameMethionine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length900
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
GO:0009267 cellular response to starvation
GO:0009303 rRNA transcription
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0032869 cellular response to insulin stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0070062 extracellular exosome
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR014758 Methionyl-tRNA synthetaseFamilyFamily
IPR015413 Methionyl/Leucyl tRNA synthetaseDomainDomain
IPR023458 Methionine-tRNA ligase, type 1FamilyFamily
IPR029038 Methionyl-tRNA synthetase, Zn-domainFamilyHomologous superfamily
IPR033911 Methioninyl-tRNA synthetase core domainDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041598 Methionine--tRNA ligase, N-terminalDomainDomain
IPR041872 Methionyl-tRNA synthetase, anticodon-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00134 MethionineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SYMC_HUMANHACD3_MOUSEIntAct25036637 details