Entity Details

Primary name HDAC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56524
EntryNameHDAC4_HUMAN
FullNameHistone deacetylase 4
TaxID9606
Evidenceevidence at protein level
Length1084
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesHDAC4

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001501 skeletal system development
GO:0002076 osteoblast development
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006476 protein deacetylation
GO:0006954 inflammatory response
GO:0007399 nervous system development
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010592 positive regulation of lamellipodium assembly
GO:0010832 negative regulation of myotube differentiation
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016575 histone deacetylation
GO:0016607 nuclear speck
GO:0017053 transcription repressor complex
GO:0019789 SUMO transferase activity
GO:0019901 protein kinase binding
GO:0030018 Z disc
GO:0030183 B cell differentiation
GO:0030955 potassium ion binding
GO:0031594 neuromuscular junction
GO:0031672 A band
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033235 positive regulation of protein sumoylation
GO:0033558 protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0040029 regulation of gene expression, epigenetic
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0042641 actomyosin
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043393 regulation of protein binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0045668 negative regulation of osteoblast differentiation
GO:0045820 negative regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048742 regulation of skeletal muscle fiber development
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0070555 response to interleukin-1
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071260 cellular response to mechanical stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071374 cellular response to parathyroid hormone stimulus
GO:1902437 positive regulation of male mating behavior
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR017320 Histone deacetylase class II, eukaryoticFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR024643 Histone deacetylase, glutamine rich N-terminal domainDomainDomain
IPR033660 Histone deacetylase 4/7FamilyFamily
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB07879 N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamideDrugbanksmall molecule
DB08613 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOLDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule