Entity Details

Primary name ITB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP11835
EntryNameITB2_MOUSE
FullNameIntegrin beta-2
TaxID10090
Evidenceevidence at protein level
Length771
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesItgb2

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001851 complement component C3b binding
GO:0002523 leukocyte migration involved in inflammatory response
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0030101 natural killer cell activation
GO:0030369 ICAM-3 receptor activity
GO:0030593 neutrophil chemotaxis
GO:0031072 heat shock protein binding
GO:0031623 receptor internalization
GO:0032930 positive regulation of superoxide anion generation
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034687 integrin alphaL-beta2 complex
GO:0034688 integrin alphaM-beta2 complex
GO:0043113 receptor clustering
GO:0043235 receptor complex
GO:0043315 positive regulation of neutrophil degranulation
GO:0043542 endothelial cell migration
GO:0044853 plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045123 cellular extravasation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050839 cell adhesion molecule binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0097242 amyloid-beta clearance
GO:0098609 cell-cell adhesion
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1990266 neutrophil migration

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015439 Integrin beta-2 subunitFamilyFamily
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
ITB2_MOUSES39A7_MOUSEIntAct15102471 details
ITB2_MOUSEKAP0_MOUSEIntAct15102471 details
ITB2_MOUSEITAM_MOUSEInnateDB20639876 details
ITB2_MOUSERL19_MOUSEBioGRID30333137 details
ITB2_MOUSESPD2B_MOUSEBioGRID30333137 details
ITB2_MOUSEHUWE1_MOUSEBioGRID30333137 details
ITB2_MOUSEUBR4_MOUSEBioGRID30333137 details
ITB2_MOUSENOP56_MOUSEBioGRID30333137 details
ITB2_MOUSEHELZ2_MOUSEBioGRID30333137 details
ITB2_MOUSELGUL_MOUSEBioGRID30333137 details
ITB2_MOUSELIMD2_MOUSEBioGRID30333137 details
ITB2_MOUSEUBP24_MOUSEBioGRID30333137 details
ITB2_MOUSEFLNA_MOUSEBioGRID30333137 details
ITB2_MOUSEFLNC_MOUSEBioGRID30333137 details
ITB2_MOUSEMYOF_MOUSEBioGRID30333137 details
ITB2_MOUSEPECR_MOUSEBioGRID30333137 details
ITB2_MOUSEXPO7_MOUSEBioGRID30333137 details
ITB2_MOUSERL6_MOUSEBioGRID30333137 details
ITB2_MOUSEGCN1_MOUSEBioGRID30333137 details
ITB2_MOUSERL15_MOUSEBioGRID30333137 details
ITB2_MOUSEPLEC_MOUSEBioGRID30333137 details
ITB2_MOUSESMC2_MOUSEBioGRID30333137 details
ITB2_MOUSESMC4_MOUSEBioGRID30333137 details
ITB2_MOUSECHD4_MOUSEBioGRID30333137 details
ITB2_MOUSECLPX_MOUSEBioGRID30333137 details
ITB2_MOUSETLN1_MOUSEBioGRID30333137 details
ITB2_MOUSEWNK1_MOUSEBioGRID30333137 details
ITB2_MOUSESON_MOUSEBioGRID30333137 details
ITB2_MOUSEBIRC6_MOUSEBioGRID30333137 details
ITB2_MOUSEITB2_MOUSEBioGRID30333137 details
ITB2_MOUSECO3_MOUSEBioGRID30333137 details
ITB2_MOUSEMAP1B_MOUSEBioGRID30333137 details
ITB2_MOUSEPRDX3_MOUSEBioGRID30333137 details
ITB2_MOUSERADI_MOUSEBioGRID30333137 details
ITB2_MOUSEUSP9X_MOUSEBioGRID30333137 details
ITB2_MOUSETCRG1_MOUSEBioGRID30333137 details
ITB2_MOUSEDREB_MOUSEBioGRID30333137 details
ITB2_MOUSERL4_MOUSEBioGRID30333137 details
ITB2_MOUSESPTB2_MOUSEBioGRID30333137 details
ITB2_MOUSENOMO1_MOUSEBioGRID30333137 details
ITB2_MOUSETPR_MOUSEBioGRID30333137 details
ITB2_MOUSEUBP2L_MOUSEBioGRID30333137 details
ITB2_MOUSEFLNB_MOUSEBioGRID30333137 details
ITB2_MOUSESRRM2_MOUSEBioGRID30333137 details
ITB2_MOUSEUTP25_MOUSEBioGRID30333137 details
ITB2_MOUSETAOK3_MOUSEBioGRID30333137 details
ITB2_MOUSEPLCG2_MOUSEBioGRID30333137 details
ITB2_MOUSEIPO11_MOUSEBioGRID30333137 details
ITB2_MOUSESF3A1_MOUSEBioGRID30333137 details
ITB2_MOUSEPSPC1_MOUSEBioGRID30333137 details
ITB2_MOUSEARPC5_MOUSEBioGRID30333137 details
ITB2_MOUSEDYHC1_MOUSEBioGRID30333137 details
ITB2_MOUSELRP1B_MOUSEMINT16601674 details
ITB2_MOUSEITAL_MOUSEDIP17785425 details
ITB2_MOUSE1433B_MOUSEBioGRID18239087 details