Entity Details

Primary name A4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP12023
EntryNameA4_MOUSE
FullNameAmyloid-beta A4 protein
TaxID10090
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesApp

GO terms

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GOName
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006378 mRNA polyadenylation
GO:0006897 endocytosis
GO:0006979 response to oxidative stress
GO:0007155 cell adhesion
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007617 mating behavior
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008306 associative learning
GO:0008542 visual learning
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0016358 dendrite development
GO:0030424 axon
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0032092 positive regulation of protein binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033130 acetylcholine receptor binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0043395 heparan sulfate proteoglycan binding
GO:0045821 positive regulation of glycolytic process
GO:0046875 ephrin receptor binding
GO:0046983 protein dimerization activity
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0051087 chaperone binding
GO:0051233 spindle midzone
GO:0051247 positive regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051402 neuron apoptotic process
GO:0070206 protein trimerization
GO:0071287 cellular response to manganese ion
GO:0090647 modulation of age-related behavioral decline
GO:1900221 regulation of amyloid-beta clearance
GO:1904646 cellular response to amyloid-beta
GO:1905906 regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1905945 regulation of response to calcium ion
GO:1990000 amyloid fibril formation
GO:0001934 positive regulation of protein phosphorylation
GO:0002265 astrocyte activation involved in immune response
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007409 axonogenesis
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0014005 microglia development
GO:0016322 neuron remodeling
GO:0016504 peptidase activator activity
GO:0019732 antifungal humoral response
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032930 positive regulation of superoxide anion generation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034364 high-density lipoprotein particle
GO:0035066 positive regulation of histone acetylation
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042056 chemoattractant activity
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050729 positive regulation of inflammatory response
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055037 recycling endosome
GO:0098815 modulation of excitatory postsynaptic potential
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902950 regulation of dendritic spine maintenance
GO:1905606 regulation of presynapse assembly
GO:1905893 positive regulation of cellular response to thapsigargin
GO:1990535 neuron projection maintenance
GO:2000406 positive regulation of T cell migration
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005158 insulin receptor binding
GO:0005641 nuclear envelope lumen
GO:0005905 clathrin-coated pit
GO:0005911 cell-cell junction
GO:0006417 regulation of translation
GO:0006878 cellular copper ion homeostasis
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008088 axo-dendritic transport
GO:0008285 negative regulation of cell population proliferation
GO:0008344 adult locomotory behavior
GO:0010628 positive regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0019731 antibacterial humoral response
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031594 neuromuscular junction
GO:0032991 protein-containing complex
GO:0034185 apolipoprotein binding
GO:0034363 intermediate-density lipoprotein particle
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0043198 dendritic shaft
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044304 main axon
GO:0045121 membrane raft
GO:0046914 transition metal ion binding
GO:0048143 astrocyte activation
GO:0048471 perinuclear region of cytoplasm
GO:0050786 RAGE receptor binding
GO:0050808 synapse organization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051262 protein tetramerization
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070555 response to interleukin-1
GO:0071280 cellular response to copper ion
GO:0071320 cellular response to cAMP
GO:0071874 cellular response to norepinephrine stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0106003 amyloid-beta complex
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903523 negative regulation of blood circulation
GO:1904022 positive regulation of G protein-coupled receptor internalization
GO:1904472 positive regulation of endothelin production
GO:1904591 positive regulation of protein import
GO:1905896 positive regulation of cellular response to tunicamycin
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:1990777 lipoprotein particle
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001664 G protein-coupled receptor binding
GO:0001774 microglial cell activation
GO:0001878 response to yeast
GO:0001967 suckling behavior
GO:0003682 chromatin binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0006468 protein phosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0009986 cell surface
GO:0009987 cellular process
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016020 membrane
GO:0016199 axon midline choice point recognition
GO:0019722 calcium-mediated signaling
GO:0019899 enzyme binding
GO:0030198 extracellular matrix organization
GO:0030426 growth cone
GO:0030546 signaling receptor activator activity
GO:0031410 cytoplasmic vesicle
GO:0032722 positive regulation of chemokine production
GO:0035253 ciliary rootlet
GO:0043393 regulation of protein binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0045177 apical part of cell
GO:0045665 negative regulation of neuron differentiation
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045931 positive regulation of mitotic cell cycle
GO:0046330 positive regulation of JNK cascade
GO:0046982 protein heterodimerization activity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048669 collateral sprouting in absence of injury
GO:0048786 presynaptic active zone
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050803 regulation of synapse structure or activity
GO:0050830 defense response to Gram-positive bacterium
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051425 PTB domain binding
GO:0060291 long-term synaptic potentiation
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070381 endosome to plasma membrane transport vesicle
GO:0070851 growth factor receptor binding
GO:0097449 astrocyte projection
GO:0150003 regulation of spontaneous synaptic transmission
GO:1900122 positive regulation of receptor binding
GO:1900181 negative regulation of protein localization to nucleus
GO:1903048 regulation of acetylcholine-gated cation channel activity
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990761 growth cone lamellipodium
GO:1990812 growth cone filopodium

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface
Cytoplasmic vesicle
Membrane
Nucleus
Secreted
Cytoplasm
Early endosome
Golgi apparatus
Cell projection
Perikaryon

Domains

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DomainNameCategoryType
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR008154 Amyloidogenic glycoprotein, extracellularDomainDomain
IPR008155 Amyloidogenic glycoproteinFamilyFamily
IPR011178 Amyloidogenic glycoprotein, copper-bindingDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptideDomainDomain
IPR015849 Amyloidogenic glycoprotein, heparin-bindingDomainDomain
IPR019543 Beta-amyloid precursor protein C-terminalDomainDomain
IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved siteSiteConserved site
IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved siteSiteConserved site
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR024329 Amyloidogenic glycoprotein, E2 domainDomainDomain
IPR028866 Amyloid-beta precursor proteinFamilyFamily
IPR036176 E2 domain superfamilyFamilyHomologous superfamily
IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamilyFamilyHomologous superfamily
IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamilyFamilyHomologous superfamily
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily
IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamilyFamilyHomologous superfamily

Diseases

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Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
A4_MOUSEAPBB1_MOUSEMINT11517249 details
A4_MOUSEAPBB1_HUMANMINT11517249 details
A4_MOUSEAPBA2_HUMANMINT11517249 details
A4_MOUSEJIP1_HUMANMINT11517249 details
A4_MOUSEAPBB2_MOUSEMINT11517249 details
A4_MOUSEAPBB3_MOUSEMINT11517249 details
A4_MOUSEDAB1_MOUSEIntAct, MINT, UniProt10460257 11517249 12826668 details
A4_MOUSENUMB_MOUSEMINT12011466 details
A4_MOUSENBL1_MOUSEMINT12011466 details
A4_MOUSEAPLP1_MOUSEBioGRID, IntAct16193067 17934213 32325033 details
A4_MOUSEAPLP2_MOUSEBioGRID, IntAct16193067 17934213 32325033 details
A4_MOUSECNTN3_HUMANIntAct18272596 details
A4_MOUSECNTN4_HUMANIntAct18272596 details
A4_MOUSEDAB2_MOUSEUniProt12826668 details
A4_MOUSESORL_MOUSEUniProt16407538 23283322 details
A4_MOUSECHIP_MOUSEBioGRID17317785 27325702 details
A4_MOUSEGGA1_MOUSEBioGRID17005855 details
A4_MOUSEUBA1_MOUSEBioGRID27325702 details
A4_MOUSEUBE2O_MOUSEBioGRID27325702 details
A4_MOUSEUB2R2_MOUSEBioGRID27325702 details
A4_MOUSEARI1_MOUSEBioGRID27325702 details
A4_MOUSEHECW1_MOUSEBioGRID27325702 details
A4_MOUSEHUWE1_MOUSEBioGRID27325702 details
A4_MOUSEKCMF1_MOUSEBioGRID27325702 details
A4_MOUSENEDD4_MOUSEBioGRID27325702 details
A4_MOUSEPARK7_MOUSEBioGRID27325702 details
A4_MOUSERNF14_MOUSEBioGRID27325702 details
A4_MOUSETRI32_MOUSEBioGRID27325702 details
A4_MOUSEUBE3A_MOUSEBioGRID27325702 details
A4_MOUSEUBR3_MOUSEBioGRID27325702 details
A4_MOUSEUBR4_MOUSEBioGRID27325702 details
A4_MOUSEUBR5_MOUSEBioGRID27325702 details
A4_MOUSECUL4A_MOUSEBioGRID27325702 details
A4_MOUSECUL4B_MOUSEBioGRID27325702 details
A4_MOUSEDDB1_MOUSEBioGRID27325702 details
A4_MOUSEDCAF5_MOUSEBioGRID27325702 details
A4_MOUSEDCAF8_MOUSEBioGRID27325702 details
A4_MOUSEFBX3_MOUSEBioGRID27325702 details
A4_MOUSEFBX21_MOUSEBioGRID27325702 details
A4_MOUSEFXL16_MOUSEBioGRID27325702 details
A4_MOUSECRBN_MOUSEBioGRID27325702 details
A4_MOUSECAND1_MOUSEBioGRID27325702 details
A4_MOUSECSN2_MOUSEBioGRID27325702 details
A4_MOUSECSN3_MOUSEBioGRID27325702 details
A4_MOUSECSN4_MOUSEBioGRID27325702 details
A4_MOUSECSN5_MOUSEBioGRID27325702 details
A4_MOUSECSN6_MOUSEBioGRID27325702 details
A4_MOUSECSN7A_MOUSEBioGRID27325702 details
A4_MOUSECSN7B_MOUSEBioGRID27325702 details
A4_MOUSECSN8_MOUSEBioGRID27325702 details
A4_MOUSEPRS4_MOUSEBioGRID27325702 details
A4_MOUSEPRS6B_MOUSEBioGRID27325702 details
A4_MOUSEPRS8_MOUSEBioGRID27325702 details
A4_MOUSEPRS10_MOUSEBioGRID27325702 details
A4_MOUSEPSMD1_MOUSEBioGRID27325702 details
A4_MOUSEPSMD2_MOUSEBioGRID27325702 details
A4_MOUSEPSMD4_MOUSEBioGRID27325702 details
A4_MOUSEPSMD7_MOUSEBioGRID27325702 details
A4_MOUSEPSMD8_MOUSEBioGRID27325702 details
A4_MOUSEPSD11_MOUSEBioGRID27325702 details
A4_MOUSEPSD12_MOUSEBioGRID27325702 details
A4_MOUSEPSD13_MOUSEBioGRID27325702 details
A4_MOUSEPSDE_MOUSEBioGRID27325702 details
A4_MOUSEUSP9X_MOUSEBioGRID27325702 details
A4_MOUSEUBP5_MOUSEBioGRID27325702 details
A4_MOUSEUBP7_MOUSEBioGRID27325702 details
A4_MOUSEUBP10_MOUSEBioGRID27325702 details
A4_MOUSEOTUB1_MOUSEBioGRID27325702 details
A4_MOUSEUBQL1_MOUSEBioGRID27325702 details
A4_MOUSEUBQL2_MOUSEBioGRID27325702 details
A4_MOUSEUBQL4_MOUSEBioGRID27325702 details
A4_MOUSEGRB2_MOUSEBioGRID27325702 details
A4_MOUSEPIN1_MOUSEBioGRID27325702 details
A4_MOUSEMIB2_MOUSEBioGRID27325702 details
A4_MOUSECBLB_MOUSEBioGRID27325702 details
A4_MOUSEUBE2N_MOUSEBioGRID27325702 details
A4_MOUSESCAM1_MOUSEBioGRID27325702 details
A4_MOUSESV2A_MOUSEBioGRID27325702 details
A4_MOUSESV2B_MOUSEBioGRID27325702 details
A4_MOUSEVAMP2_MOUSEBioGRID27325702 details
A4_MOUSEVPP1_MOUSEBioGRID27325702 details
A4_MOUSEVGLU1_MOUSEBioGRID27325702 details
A4_MOUSESYT1_MOUSEBioGRID27325702 details
A4_MOUSESYT2_MOUSEBioGRID27325702 details
A4_MOUSERAB14_MOUSEBioGRID27325702 details
A4_MOUSERAB3A_MOUSEBioGRID27325702 details
A4_MOUSESNP25_MOUSEBioGRID27325702 details
A4_MOUSESYN2_MOUSEBioGRID27325702 details
A4_MOUSESYN1_MOUSEBioGRID27325702 details
A4_MOUSEAPOE_MOUSEBioGRID27325702 details
A4_MOUSETAU_MOUSEBioGRID27325702 details
A4_MOUSEJIP1_MOUSEMINT11517249 11724784 details
A4_MOUSEAPBA2_MOUSEIntAct, MINT11517249 20925061 details
A4_MOUSESHC3_MOUSEIntAct11877420 details
A4_MOUSEPRIO_MOUSEBioGRID, IntAct15146195 17934213 details
A4_MOUSELIGO1_MOUSEIntAct17934213 details
A4_MOUSECSTN1_MOUSEIntAct17934213 20925061 details
A4_MOUSECALR_MOUSEIntAct17934213 23585889 details
A4_MOUSEPIN1_HUMANIntAct16554819 details
A4_MOUSEA4_MOUSEMINT20573181 details
A4_MOUSEDLG4_MOUSEMINT20573181 details
A4_MOUSES40A1_MOUSEIntAct20817278 details
A4_MOUSEITM2B_MOUSEMINT21587206 details
A4_MOUSEGNAO_MOUSEIntAct23761911 details
A4_MOUSEFLRT3_MOUSEUniProt26960425 details
A4_MOUSEITM2B_HUMANUniProt16027166 details
A4_MOUSESORT_MOUSEUniProt23283322 details
A4_MOUSEPPID_MOUSEUniProt18806802 details
A4_MOUSERGRF1_MOUSEMINT23719799 details
A4_MOUSESYUA_MOUSEBioGRID18769546 details
A4_MOUSECPEB1_MOUSEBioGRID16314516 details
A4_MOUSERANB9_MOUSEBioGRID19251705 details
A4_MOUSEVGFR2_MOUSEBioGRID19818105 details
A4_MOUSEM3K5_MOUSEBioGRID17719230 details
A4_MOUSETNR16_MOUSEBioGRID19334058 details
A4_MOUSERELN_MOUSEBioGRID10939329 19515914 details
A4_MOUSECLUS_MOUSEBioGRID30295351 details
A4_MOUSEEGF_MOUSEBioGRID33009641 details