Entity Details

Primary name RHOA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61586
EntryNameRHOA_HUMAN
FullNameTransforming protein RhoA
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesRHOA

GO terms

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GOName
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016032 viral process
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0017022 myosin binding
GO:0019901 protein kinase binding
GO:0021762 substantia nigra development
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030054 cell junction
GO:0030334 regulation of cell migration
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0030865 cortical cytoskeleton organization
GO:0031122 cytoplasmic microtubule organization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031532 actin cytoskeleton reorganization
GO:0031982 vesicle
GO:0032154 cleavage furrow
GO:0032467 positive regulation of cytokinesis
GO:0032956 regulation of actin cytoskeleton organization
GO:0033688 regulation of osteoblast proliferation
GO:0034329 cell junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035385 Roundabout signaling pathway
GO:0036089 cleavage furrow formation
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042995 cell projection
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043149 stress fiber assembly
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043296 apical junction complex
GO:0043297 apical junction assembly
GO:0043312 neutrophil degranulation
GO:0043542 endothelial cell migration
GO:0043931 ossification involved in bone maturation
GO:0044319 wound healing, spreading of cells
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045666 positive regulation of neuron differentiation
GO:0045792 negative regulation of cell size
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050919 negative chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060193 positive regulation of lipase activity
GO:0061383 trabecula morphogenesis
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090307 mitotic spindle assembly
GO:0097498 endothelial tube lumen extension
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0101003 ficolin-1-rich granule membrane
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902766 skeletal muscle satellite cell migration
GO:1903673 mitotic cleavage furrow formation
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:1990869 cellular response to chemokine
GO:2000145 regulation of cell motility
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cleavage furrow
Cytoplasm
Midbody

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule