Entity Details

Primary name PP1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62136
EntryNamePP1A_HUMAN
FullNameSerine/threonine-protein phosphatase PP1-alpha catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length330
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPPP1CA

GO terms

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GOName
GO:0000164 protein phosphatase type 1 complex
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005977 glycogen metabolic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005981 regulation of glycogen catabolic process
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0008157 protein phosphatase 1 binding
GO:0010288 response to lead ion
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0016791 phosphatase activity
GO:0030324 lung development
GO:0032091 negative regulation of protein binding
GO:0032922 circadian regulation of gene expression
GO:0035970 peptidyl-threonine dephosphorylation
GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation
GO:0042587 glycogen granule
GO:0042752 regulation of circadian rhythm
GO:0043021 ribonucleoprotein complex binding
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0046872 metal ion binding
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051301 cell division
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0070062 extracellular exosome
GO:0070262 peptidyl-serine dephosphorylation
GO:0072357 PTW/PP1 phosphatase complex
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1904886 beta-catenin destruction complex disassembly
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR031675 Serine-threonine protein phosphatase, N-terminalDomainDomain
IPR037979 Serine/threonine-protein phosphatase PP1-alpha catalytic subunitFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule