Entity Details

Primary name FKB1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62942
EntryNameFKB1A_HUMAN
FullNamePeptidyl-prolyl cis-trans isomerase FKBP1A
TaxID9606
Evidenceevidence at protein level
Length108
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesFKBP1A

GO terms

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GOName
GO:0000413 protein peptidyl-prolyl isomerization
GO:0003007 heart morphogenesis
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005527 macrolide binding
GO:0005528 FK506 binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0014802 terminal cisterna
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0022417 protein maturation by protein folding
GO:0030018 Z disc
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031312 extrinsic component of organelle membrane
GO:0031398 positive regulation of protein ubiquitination
GO:0032092 positive regulation of protein binding
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032880 regulation of protein localization
GO:0032925 regulation of activin receptor signaling pathway
GO:0034713 type I transforming growth factor beta receptor binding
GO:0042026 protein refolding
GO:0042110 T cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044325 transmembrane transporter binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050776 regulation of immune response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347 heart trabecula formation
GO:0061077 chaperone-mediated protein folding
GO:0070588 calcium ion transmembrane transport
GO:0097435 supramolecular fiber organization
GO:0098562 cytoplasmic side of membrane
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1990000 amyloid fibril formation
GO:1990425 ryanodine receptor complex

Subcellular Location

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Subcellular Location
Cytoplasm
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00337 PimecrolimusDrugbanksmall molecule
DB00864 TacrolimusDrugbanksmall molecule
DB00877 SirolimusDrugbanksmall molecule
DB01712 (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl esterDrugbanksmall molecule
DB01723 {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic AcidDrugbanksmall molecule
DB01951 Gpi-1046Drugbanksmall molecule
DB02311 Methyl Methylsulfinylmethyl SulfideDrugbanksmall molecule
DB02888 FKB-001Drugbanksmall molecule
DB03338 Heptyl glucosideDrugbanksmall molecule
DB03621 L-709,587Drugbanksmall molecule
DB04012 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-LeucineDrugbanksmall molecule
DB04094 4-hydroxybutan-2-oneDrugbanksmall molecule
DB05814 GPI-1485Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08520 (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANEDrugbanksmall molecule
DB08597 DorsomorphinDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FKB1A_HUMANMTOR_MOUSEBioGRID9334222 details