Entity Details

Primary name GRB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62993
EntryNameGRB2_HUMAN
FullNameGrowth factor receptor-bound protein 2
TaxID9606
Evidenceevidence at protein level
Length217
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesGRB2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007568 aging
GO:0008180 COP9 signalosome
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0012506 vesicle membrane
GO:0016032 viral process
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030674 protein-macromolecule adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0031623 receptor internalization
GO:0035635 entry of bacterium into host cell
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770 signal transduction in response to DNA damage
GO:0042802 identical protein binding
GO:0043408 regulation of MAPK cascade
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046875 ephrin receptor binding
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070436 Grb2-EGFR complex
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR035641 GRB2, N-terminal SH3 domainDomainDomain
IPR035643 GRB2, C-terminal SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00061 PegademaseDrugbankbiotech
DB03276 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic AcidDrugbanksmall molecule