Entity Details

Primary name RAC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63000
EntryNameRAC1_HUMAN
FullNameRas-related C3 botulinum toxin substrate 1
TaxID9606
Evidenceevidence at protein level
Length192
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesRAC1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0002551 mast cell chemotaxis
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006954 inflammatory response
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007596 blood coagulation
GO:0008045 motor neuron axon guidance
GO:0008283 cell population proliferation
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010591 regulation of lamellipodium assembly
GO:0010592 positive regulation of lamellipodium assembly
GO:0010595 positive regulation of endothelial cell migration
GO:0010764 negative regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016020 membrane
GO:0016601 Rac protein signal transduction
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030334 regulation of cell migration
GO:0030667 secretory granule membrane
GO:0030865 cortical cytoskeleton organization
GO:0031116 positive regulation of microtubule polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0031343 positive regulation of cell killing
GO:0031410 cytoplasmic vesicle
GO:0031529 ruffle organization
GO:0031996 thioesterase binding
GO:0032587 ruffle membrane
GO:0032707 negative regulation of interleukin-23 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042470 melanosome
GO:0042826 histone deacetylase binding
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0043652 engulfment of apoptotic cell
GO:0044877 protein-containing complex binding
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0045740 positive regulation of DNA replication
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048870 cell motility
GO:0050690 regulation of defense response to virus by virus
GO:0051022 Rho GDP-dissociation inhibitor binding
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051117 ATPase binding
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051668 localization within membrane
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0055038 recycling endosome membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060263 regulation of respiratory burst
GO:0070062 extracellular exosome
GO:0071260 cellular response to mechanical stimulus
GO:0071526 semaphorin-plexin signaling pathway
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0097178 ruffle assembly
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0101003 ficolin-1-rich granule membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902622 regulation of neutrophil migration

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Melanosome

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule