Entity Details

Primary name GNAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63092
EntryNameGNAS2_HUMAN
FullNameGuanine nucleotide-binding protein G(s) subunit alpha isoforms short
TaxID9606
Evidenceevidence at protein level
Length394
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesGNAS

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0010856 adenylate cyclase activator activity
GO:0016020 membrane
GO:0031224 intrinsic component of membrane
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0032588 trans-Golgi network membrane
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0046872 metal ion binding
GO:0046907 intracellular transport
GO:0048589 developmental growth
GO:0050796 regulation of insulin secretion
GO:0050890 cognition
GO:0060348 bone development
GO:0060789 hair follicle placode formation
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071870 cellular response to catecholamine stimulus
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000367 G-protein alpha subunit, group SFamilyFamily
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02587 ColforsinDrugbanksmall molecule
DB06843 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDrugbanksmall molecule

Interactions

3 interactions