Entity Details

Primary name SKP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63208
EntryNameSKP1_HUMAN
FullNameS-phase kinase-associated protein 1
TaxID9606
Evidenceevidence at protein level
Length163
SequenceStatuscomplete
DateCreated2004-09-27
DateModified2021-06-02

Ontological Relatives

GenesSKP1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006879 cellular iron ion homeostasis
GO:0008013 beta-catenin binding
GO:0010265 SCF complex assembly
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0019904 protein domain specific binding
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0035518 histone H2A monoubiquitination
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051457 maintenance of protein location in nucleus
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070936 protein K48-linked ubiquitination
GO:0097602 cullin family protein binding
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1990444 F-box domain binding
GO:1990756 ubiquitin ligase-substrate adaptor activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001232 S-phase kinase-associated protein 1-likeFamilyFamily
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR016072 SKP1 component, dimerisationDomainDomain
IPR016073 SKP1 component, POZ domainDomainDomain
IPR016897 S-phase kinase-associated protein 1FamilyFamily
IPR036296 SKP1-like, dimerisation domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01750 1-naphthaleneacetic acidDrugbanksmall molecule
DB06980 (2S)-2-(1H-indol-3-yl)hexanoic acidDrugbanksmall molecule
DB06981 (2S)-2-(1H-indol-3-yl)pentanoic acidDrugbanksmall molecule
DB06982 (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acidDrugbanksmall molecule
DB07950 Indoleacetic acidDrugbanksmall molecule