Entity Details

Primary name RACK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63244
EntryNameRACK1_HUMAN
FullNameReceptor of activated protein C kinase 1
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesRACK1

GO terms

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GOName
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0003723 RNA binding
GO:0005080 protein kinase C binding
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007369 gastrulation
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010629 negative regulation of gene expression
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0015935 small ribosomal subunit
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030308 negative regulation of cell growth
GO:0030332 cyclin binding
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030496 midbody
GO:0030971 receptor tyrosine kinase binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880 regulation of protein localization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043204 perikaryon
GO:0043547 positive regulation of GTPase activity
GO:0045296 cadherin binding
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051434 BH3 domain binding
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0071333 cellular response to glucose stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0072344 rescue of stalled ribosome
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1990630 IRE1-RACK1-PP2A complex
GO:2000114 regulation of establishment of cell polarity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
RACK1_HUMANB2L11_MOUSEIntAct18420585 details
RACK1_HUMANPIAS2_MOUSEMINT22210188 details