Entity Details

Primary name PP2AA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP67775
EntryNamePP2AA_HUMAN
FullNameSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length309
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesPPP2CA

GO terms

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GOName
GO:0000159 protein phosphatase type 2A complex
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 obsolete inactivation of MAPK activity
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0001932 regulation of protein phosphorylation
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007084 mitotic nuclear membrane reassembly
GO:0007498 mesoderm development
GO:0008022 protein C-terminus binding
GO:0008380 RNA splicing
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0019932 second-messenger-mediated signaling
GO:0030111 regulation of Wnt signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0035970 peptidyl-threonine dephosphorylation
GO:0040008 regulation of growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045595 regulation of cell differentiation
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048156 tau protein binding
GO:0050811 GABA receptor binding
GO:0051321 meiotic cell cycle
GO:0070062 extracellular exosome
GO:0070262 peptidyl-serine dephosphorylation
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1904526 regulation of microtubule binding
GO:1904528 positive regulation of microtubule binding

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDrugbanksmall molecule