Entity Details

Primary name EF1A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP68104
EntryNameEF1A1_HUMAN
FullNameElongation factor 1-alpha 1
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesEEF1A1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005516 calmodulin binding
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0005886 plasma membrane
GO:0006412 translation
GO:0006414 translational elongation
GO:0016020 membrane
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030864 cortical actin cytoskeleton
GO:0032587 ruffle membrane
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0070062 extracellular exosome
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098574 cytoplasmic side of lysosomal membrane
GO:1900022 regulation of D-erythro-sphingosine kinase activity
GO:1904714 regulation of chaperone-mediated autophagy
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminalDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR004539 Translation elongation factor EF1A, eukaryotic/archaealFamilyFamily
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

3 interactions